Acetyl-CoA carboxylase
A PROTEIN COMPLEX THAT CATALYZES THE FIRST STEP IN LONG-CHAIN FATTY ACID BIOSYNTHESIS. FOR EXAMPLE, IN E. COLI THE COMPLEX IS HETEROHEXAMERIC AND COMPOSED OF BIOTIN CARBONYL CARRIER PROTEIN, BIOTIN CARBOXYLASE AND THE ACETATE COA-TRANSFERASE COMPLEX.
Acetyl-coa carboxylase; ACCase; Acetyl coa carboxylase; Acetyl CoA carboxylase; EC 6.4.1.2; Acetyl-CoA:carbon-dioxide ligase (ADP-forming); Acetyl coenzyme A carboxylase; TaACC
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme () that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the cytoplasm of most eukaryotes.